Older people and preventive home visits

In 1996, national preventive efforts for the elderly were introduced in Denmark with a general offer of home visits by preventive staff.The focal point of the preventive home visits has been the functional decline and the corresponding early and coordinated follow-up activities. This has proved an extremely suitable instrument in activities aimed at maintaining elderly people's autonomy, independence, and functional ability, in allowing them to continue taking care of themselves

Analysis of Landscape geographic Impacts of Potential Climate Change in Hungary

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Multi-color Cavity Metrology

Long baseline laser interferometers used for gravitational wave detection have proven to be very complicated to control. In order to have sufficient sensitivity to astrophysical gravitational waves, a set of multiple coupled optical cavities comprising the interferometer must be brought into resonance with the laser field. A set of multi-input, multi-output servos then lock these cavities into place via feedback control. This procedure, known as lock acquisition, has proven to be a vexing problem and has reduced greatly the reliability and duty factor of the past generation of laser interferometers. In this article, we describe a technique for bringing the interferometer from an uncontrolled state into resonance by using harmonically related external fields to provide a deterministic hierarchical control. This technique reduces the effect of the external seismic disturbances by four orders of magnitude and promises to greatly enhance the stability and reliability of the current generation of gravitational wave detector. The possibility for using multi-color techniques to overcome current quantum and thermal noise limits is also discussed

Phenotyping shows improved physiological traits and seed yield of transgenic wheat plants expressing the alfalfa aldose reductase under permanent drought stress

Members of the aldo-keto reductase family including aldose reductases are involved in antioxidant defense by metabolizing a wide range of lipid peroxidation-derived cytotoxic compounds. Therefore, we produced transgenic wheat genotypes over-expressing the cDNA of alfalfa aldose reductase gene. These plants consequently exhibit 1.5-4.3 times higher detoxification activity for the aldehyde substrate. Permanent drought stress was generated in the greenhouse by growing wheat plants in soil with 20 % water capacity. The control and stressed plants were monitored by a semi automatic phenotyping platform providing computer-controlled watering, digital and thermal imaging. Calculation of biomass values was based on the correlation (R2 = 0.7556) between fresh weight and green pixel-based shoot surface area. The green biomass production by plants of the three transgenic lines was 12-26-41 % higher than the non-transgenic plants' grown under water limitation. Thermal imaging of stressed non-transgenic plants indicated an elevation in the leaf temperature. The thermal status of transformants was similar at both normal and suboptimal water regime. In drought, the transgenic plants used more water during the growing season. The described phenotyping platform provided a comprehensive data set demonstrating the improved physiological condition of the drought stressed transgenic wheat plants in the vegetative growth phase. In soil with reduced water capacity two transgenic genotypes showed higher seed weight per plant than the control non-transgenic one. Limitation of greenhouse-based phenotyping in analysis of yield potential is discussed. © 2013 The Author(s)

Phase-space structures II: Hierarchical Structure Finder

A new multi-dimensional Hierarchical Structure Finder (HSF) to study the phase-space structure of dark matter in N-body cosmological simulations is presented. The algorithm depends mainly on two parameters, which control the level of connectivity of the detected structures and their significance compared to Poisson noise. By working in 6D phase-space, where contrasts are much more pronounced than in 3D position space, our HSF algorithm is capable of detecting subhaloes including their tidal tails, and can recognise other phase-space structures such as pure streams and candidate caustics. If an additional unbinding criterion is added, the algorithm can be used as a self-consistent halo and subhalo finder. As a test, we apply it to a large halo of the Millennium Simulation, where 19 % of the halo mass are found to belong to bound substructures, which is more than what is detected with conventional 3D substructure finders, and an additional 23-36 % of the total mass belongs to unbound HSF structures. The distribution of identified phase-space density peaks is clearly bimodal: high peaks are dominated by the bound structures and low peaks belong mostly to tidal streams. In order to better understand what HSF provides, we examine the time evolution of structures, based on the merger tree history. Bound structures typically make only up to 6 orbits inside the main halo. Still, HSF can identify at the present time at least 80 % of the original content of structures with a redshift of infall as high as z <= 0.3, which illustrates the significant power of this tool to perform dynamical analyses in phase-space.Comment: Submitted to MNRAS, 24 pages, 18 figure

Time sequence of the damage to the acceptor and donor sides of photosystem II by UV-B radiation as evaluated by chlorophyll a fluorescence

The effects of ultraviolet-B (UV-B) radiation on photosystem II (PS II) were studied in leaves of Chenopodium album. After the treatment with UV-B the damage was estimated using chlorophyll a fluorescence techniques. Measurements of modulated fluorescence using a pulse amplitude modulated fluorometer revealed that the efficiency of photosystem II decreased both with increasing time of UV-B radiation and with increasing intensity of the UV-B. Fluorescence induction rise curves were analyzed using a mechanistic model of energy trapping. It appears that the damage by UV-B radiation occurs first at the acceptor side of photosystem II, and only later at the donor side

Simultaneous non-negative matrix factorization for multiple large scale gene expression datasets in toxicology

Non-negative matrix factorization is a useful tool for reducing the dimension of large datasets. This work considers simultaneous non-negative matrix factorization of multiple sources of data. In particular, we perform the first study that involves more than two datasets. We discuss the algorithmic issues required to convert the approach into a practical computational tool and apply the technique to new gene expression data quantifying the molecular changes in four tissue types due to different dosages of an experimental panPPAR agonist in mouse. This study is of interest in toxicology because, whilst PPARs form potential therapeutic targets for diabetes, it is known that they can induce serious side-effects. Our results show that the practical simultaneous non-negative matrix factorization developed here can add value to the data analysis. In particular, we find that factorizing the data as a single object allows us to distinguish between the four tissue types, but does not correctly reproduce the known dosage level groups. Applying our new approach, which treats the four tissue types as providing distinct, but related, datasets, we find that the dosage level groups are respected. The new algorithm then provides separate gene list orderings that can be studied for each tissue type, and compared with the ordering arising from the single factorization. We find that many of our conclusions can be corroborated with known biological behaviour, and others offer new insights into the toxicological effects. Overall, the algorithm shows promise for early detection of toxicity in the drug discovery process

Human hippocampal theta power indicates movement onset and distance travelled

Theta frequency oscillations in the 6- to 10-Hz range dominate the rodent hippocampal local field potential during translational movement, suggesting that theta encodes self-motion. Increases in theta power have also been identified in the human hippocampus during both real and virtual movement but appear as transient bursts in distinct high- and low-frequency bands, and it is not yet clear how these bursts relate to the sustained oscillation observed in rodents. Here, we examine depth electrode recordings from the temporal lobe of 13 presurgical epilepsy patients performing a selfpaced spatial memory task in a virtual environment. In contrast to previous studies, we focus on movement-onset periods that incorporate both initial acceleration and an immediately preceding stationary interval associated with prominent theta oscillations in the rodent hippocampal formation. We demonstrate that movementonset periods are associated with a significant increase in both low (2–5 Hz)- and high (6–9 Hz)-frequency theta power in the human hippocampus. Similar increases in low- and high-frequency theta power are seen across lateral temporal lobe recording sites and persist throughout the remainder of movement in both regions. In addition, we show that movement-related theta power is greater both before and during longer paths, directly implicating human hippocampal theta in the encoding of translational movement. These findings strengthen the connection between studies of theta-band activity in rodents and humans and offer additional insight into the neural mechanisms of spatial navigation

Dissipational versus Dissipationless Galaxy Formation and the Dark Matter Content of Galaxies

We examine two extreme models for the build-up of the stellar component of luminous elliptical galaxies. In one case, we assume the build-up of stars is dissipational, with centrally accreted gas radiating away its orbital and thermal energy; the dark matter halo will undergo adiabatic contraction and the central dark matter density profile will steepen. For the second model, we assume the central galaxy is assembled by a series of dissipationless mergers of stellar clumps that have formed far from the nascent galaxy. In order to be accreted, these clumps lose their orbital energy to the dark matter halo via dynamical friction, thereby heating the central dark matter and smoothing the dark matter density cusp. The central dark matter density profiles differ drastically between these models. For the isolated elliptical galaxy, NGC 4494, the central dark matter densities follow the power-laws r^(-0.2) and r^(-1.7) for the dissipational and dissipationless models, respectively. By matching the dissipational and dissipationless models to observations of the stellar component of elliptical galaxies, we examine the relative contributions of dissipational and dissipationless mergers to the formation of elliptical galaxies and look for observational tests that will distinguish between these models. Comparisons to strong lensing brightest cluster galaxies yield median M*/L_B ratios of 2.1+/-0.8 and 5.2+/-1.7 at z=0.39 for the dissipational and dissipationless models, respectively. For NGC 4494, the best-fit dissipational and dissipationless models have M*/L_B=2.97 and 3.96. Comparisons to expected stellar mass-to-light ratios from passive evolution and population syntheses appear to rule out a purely dissipational formation mechanism for the central stellar regions of giant elliptical galaxies.Comment: 15 pages, 9 figures, accepted to Ap